Foundations of regenerative biology and medicine /
David L. Stocum.
- 1 online resource (various pagings) : illustrations (some color).
- [IOP release 5] IOP expanding physics, 2053-2563 .
- IOP (Series). Release 5. IOP expanding physics. .
"Version: 20181001"--Title page verso.
Includes bibliographical references.
part I. Regenerative biology. 1. Regeneration -- 1.1. Introduction -- 1.2. Who and what regenerates? -- 1.3. A brief history of regenerative biology -- 1.4. The regenerative niche -- 1.5. Approaches to the study of regeneration -- 1.6. Mechanism 2. Wound repair by fibrosis -- 2.1. Fibrosis is studied primarily in skin -- 2.2. Structure and function of skin -- 2.3. Types of wounds -- 2.4. Stages of repair in acute wounds -- 2.5. Aging reduces the repair capacity of acute skin wounds -- 2 3. Regeneration by adult stem cells -- 3.1. Epithelial stem cells -- 3.2. Mesenchymal stem cells -- 3.3. Stem cells in non-regenerating organs 4. Non-stem cell regenerative mechanisms -- 4.1. Cellular re-growth: axon regeneration -- 4.2. Regeneration from pre-existing differentiated cells -- 4.3. Transdifferentiation: newt lens and retina 5. Appendage regeneration -- 5.1. Limb regeneration in urodele amphibians -- 5.2. Appendage regeneration in Xenopus -- 5.3. Mouse digit tip regeneration -- 5.4. Regeneration of mouse ear tissue -- 5.5. Regeneration of deer antlers -- 5.6. Enhanc part II. Regenerative medicine. 6. Strategies of regenerative medicine -- 6.1. Historical notes -- 6.2. Biomimetic devices and organ transplants -- 6.3. Pharmaceutical induction of regeneration in situ -- 6.4. Cell transplants -- 6.5. Biomimetic 7. Pharmaceutical therapies for wound repair and regeneration -- 7.1. Skin -- 7.2. Neural tissues -- 7.3. Musculoskeletal tissues -- 7.4. Cardiac muscle 8. Cell transplants as regenerative therapy -- 8.1. Skin -- 8.2. Neural tissues -- 8.3. Liver and pancreas -- 8.4. Musculoskeletal tissues -- 8.5. Cardiac tissues -- 8.6. Hematopoietic deficiency disorders 9. Biomimetic tissues and organs -- 9.1. Skin -- 9.2. Muscle -- 9.3. Bone -- 9.4. Articular cartilage -- 9.5. Cardiovascular tissue -- 9.6. Liver and pancreas -- 9.7. Airways -- 9.8. Kidney and bladder 10. Into the adjacent possible -- 10.1. Technical innovations -- 10.2. Applications of edge technologies -- 10.3. Bioethics in regenerative medicine -- 10.4. Concluding statement.
Regenerative biology and medicine is a rapidly developing field that can revolutionize medicine. It is a nexus of convergent science, drawing from chemistry, physics, mathematics and bioengineering. Foundations of Regenerative Biology and Medici
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David L Stocum is Emeritus Professor of Biology and Emeritus Dean of the School of Science at Indiana University-Purdue University Indianapolis. He holds undergraduate degrees in Biology and Psychology from Susquehanna University, a MS in Zoolog