Multiscale modeling of vascular dynamics of micro- and nano-particles : application to drug delivery system / Huilin Ye, Zhiqiang Shen and Ying Li.

By: Ye, Huilin (Mechanical engineer) [author.]Contributor(s): Shen, Zhiqiang (Mechanical engineer) [author.] | Li, Ying (Ph. D. in mechanical engineering) [author.] | Morgan & Claypool Publishers [publisher.] | Institute of Physics (Great Britain) [publisher.]Material type: TextTextSeries: IOP (Series)Release 6 | IOP concise physicsPublisher: San Rafael [California] (40 Oak Drive, San Rafael, CA, 94903, USA) : Morgan & Claypool Publishers, [2019]Distributor: Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2019]Description: 1 online resource (various pagings) : illustrations (some color)Content type: text Media type: electronic Carrier type: online resourceISBN: 9781643277929 ebookSubject(s): Drug targeting | Drug carriers (Pharmacy) | Nanoparticles -- Therapeutic use | Blood-vessels | Biomechanics | Biomedical materials -- Mechanical properties | Multiscale modeling | Drug Delivery Systems | Drug Carriers | Nanoparticles -- therapeutic use | Blood Vessels -- physiology | Biocompatible Materials | Biomechanical Phenomena | Models, Anatomic | Models, Biological | Biophysics | SCIENCE / Life Sciences / BiophysicsAdditional physical formats: Print version:: No titleDDC classification: 615.7 LOC classification: RM301.63 .Y456 2019ebNLM classification: QV 785Online resources: e-book Full-text access Also available in print.
Contents:
1. Background -- 1.1. Blood flow in human vasculature -- 1.2. Vascular targeting and margination of particles in blood flow -- 1.3. Adhesion of particles on endothelium wall
part I. Numerical method -- 2. Numerical methods: fluid-structure interaction and adhesive dynamics -- 2.1. Fluid-structure interaction -- 2.2. Adhesive dynamics -- 2.3. Validation of numerical method
part II. Applications -- 3. Anomalous vascular dynamics of nanoworms within blood flow -- 3.1. Motivation -- 3.2. Experimental and computational results
4. Adhesion behavior of a single cell on the endothelial wall -- 4.1. Introduction -- 4.2. Computational model -- 4.3. Results and discussion
5. Localization of soft particles: margination and adhesion -- 5.1. Introduction -- 5.2. Physical problem and computational method -- 5.3. Results and discussion
6. Shape-dependent transport of micro-particles in blood flow: from margination to adhesion -- 6.1. Introduction -- 6.2. Computational model setup -- 6.3. Results and discussion
7. Conclusion and perspective -- Appendix A. Coarse-grained potential for RBCs.
Abstract: Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of dr

"Version: 20191201"--Title page verso.

"A Morgan & Claypool publication as part of IOP Concise Physics"--Title page verso.

Includes bibliographical references.

1. Background -- 1.1. Blood flow in human vasculature -- 1.2. Vascular targeting and margination of particles in blood flow -- 1.3. Adhesion of particles on endothelium wall

part I. Numerical method -- 2. Numerical methods: fluid-structure interaction and adhesive dynamics -- 2.1. Fluid-structure interaction -- 2.2. Adhesive dynamics -- 2.3. Validation of numerical method

part II. Applications -- 3. Anomalous vascular dynamics of nanoworms within blood flow -- 3.1. Motivation -- 3.2. Experimental and computational results

4. Adhesion behavior of a single cell on the endothelial wall -- 4.1. Introduction -- 4.2. Computational model -- 4.3. Results and discussion

5. Localization of soft particles: margination and adhesion -- 5.1. Introduction -- 5.2. Physical problem and computational method -- 5.3. Results and discussion

6. Shape-dependent transport of micro-particles in blood flow: from margination to adhesion -- 6.1. Introduction -- 6.2. Computational model setup -- 6.3. Results and discussion

7. Conclusion and perspective -- Appendix A. Coarse-grained potential for RBCs.

Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of dr

Professional and scholarly.

Also available in print.

Mode of access: World Wide Web.

System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.

Huilin Ye is a Ph.D. candidate in Mechanical Engineering at the University of Connecticut. His research interest is mainly on developing high-fidelity computational methods in biosystems, especially for the blood flow. The key tasks include two

Title from PDF title page (viewed on January 6, 2020).