Physics of cancer. Volume 2, Cellular and microenvironmental effects / Claudia Tanja Mierke.

By: Mierke, Claudia Tanja [author.]Contributor(s): Institute of Physics, IOP - EBA (Great Britain) [publisher.]Material type: TextTextSeries: IOP (Series)Release 5 | IOP expanding physics | Biophysical Society seriesPublisher: Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2018]Edition: Second editionDescription: 1 online resource (various pagings) : illustrations (chiefly color)Content type: text Media type: electronic Carrier type: online resourceISBN: 9780750321174 ebookOther title: Cellular and microenvironmental effectsSubject(s): Cancer cells -- Mechanical properties | Cancer | Biophysics | Pathology, Molecular | Cell Transformation, Neoplastic | Cell Physiological Phenomena | Tumor Microenvironment | Biomechanical Phenomena | Biophysics | SCIENCE / Life Sciences / BiophysicsAdditional physical formats: Print version:: No titleDDC classification: 616.994 LOC classification: RC262 .M547 2018eb vol. 2NLM classification: QZ 203Online resources: e-book Full-text access Also available in print.
Contents:
part IV. The effect of microtubules and the mechanical properties of the nucleus on matrix invasion -- 9. Microtubules during migration and matrix invasion -- 9.1. The structure and assembly of microtubules -- 9.2. The assembly of the mitotic sp
10. Nuclear deformability during migration and matrix invasion -- 10.1. The physical role of the nucleus in cell migration -- 10.2. Mechanical properties of the nucleus -- 10.3. Nucleus-cytoskeleton-extracellular matrix connections -- 10.4. Mech
part V. The impact of the tumor microenvironment on cellular invasion -- 11. The mechanical and structural properties of the microenvironment -- 11.1. Why is the extracellular matrix of connective tissue crucial for the invasion of cancer cells?
12. The impact of cells and substances within the extracellular matrix tissue on mechanical properties and cell invasion -- 12.1. The impact of tumor-associated fibroblasts on matrix mechanical properties -- 12.2. Cancer-associated fibroblasts a
13. The active role of the tumor stroma in regulating cell invasion -- 13.1. The stroma enhances malignant cancer progression -- 13.2. Biomechanical alterations in cancer cells -- 13.3. Extracellular matrix evoked alterations in cancer cell func
part VI. The impact of the mechanical and biochemical interaction of cancer cells with other cells in transendothelial migration -- 14. The impact of the mechanical and biochemical interaction of cancer cells with other cells in transendothelial
15. The mechanical properties of endothelial cells altered by aggressive cancer cells -- 15.1. The role of endothelial cell stiffness -- 15.2. The role of the endothelial contractile apparatus -- 15.3. Interaction between cancer cells and endoth
16. The role of macrophages during cancer cell transendothelial migration -- 16.1. What is the role of macrophages during cancer disease? -- 16.2. Impact of Mena on cancer cell invasion and macrophages -- 16.3. Impact of Mena on macrophages -- 1
Abstract: In order to increase the healing opportunities of cancer, it is important to impair the dissemination and the spreading of cancer cells from the initial tumor and the formation of metastases in other organs or tissues of the human body. The unde

"Version: 20181001"--Title page verso.

Includes bibliographical references.

part IV. The effect of microtubules and the mechanical properties of the nucleus on matrix invasion -- 9. Microtubules during migration and matrix invasion -- 9.1. The structure and assembly of microtubules -- 9.2. The assembly of the mitotic sp

10. Nuclear deformability during migration and matrix invasion -- 10.1. The physical role of the nucleus in cell migration -- 10.2. Mechanical properties of the nucleus -- 10.3. Nucleus-cytoskeleton-extracellular matrix connections -- 10.4. Mech

part V. The impact of the tumor microenvironment on cellular invasion -- 11. The mechanical and structural properties of the microenvironment -- 11.1. Why is the extracellular matrix of connective tissue crucial for the invasion of cancer cells?

12. The impact of cells and substances within the extracellular matrix tissue on mechanical properties and cell invasion -- 12.1. The impact of tumor-associated fibroblasts on matrix mechanical properties -- 12.2. Cancer-associated fibroblasts a

13. The active role of the tumor stroma in regulating cell invasion -- 13.1. The stroma enhances malignant cancer progression -- 13.2. Biomechanical alterations in cancer cells -- 13.3. Extracellular matrix evoked alterations in cancer cell func

part VI. The impact of the mechanical and biochemical interaction of cancer cells with other cells in transendothelial migration -- 14. The impact of the mechanical and biochemical interaction of cancer cells with other cells in transendothelial

15. The mechanical properties of endothelial cells altered by aggressive cancer cells -- 15.1. The role of endothelial cell stiffness -- 15.2. The role of the endothelial contractile apparatus -- 15.3. Interaction between cancer cells and endoth

16. The role of macrophages during cancer cell transendothelial migration -- 16.1. What is the role of macrophages during cancer disease? -- 16.2. Impact of Mena on cancer cell invasion and macrophages -- 16.3. Impact of Mena on macrophages -- 1

In order to increase the healing opportunities of cancer, it is important to impair the dissemination and the spreading of cancer cells from the initial tumor and the formation of metastases in other organs or tissues of the human body. The unde

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Claudia Tanja Mierke has a background in biology and molecular oncology and is head of the biological physics division at the University of Leipzig where she regularly teaches molecular and cell biology, biophysics and soft matter physics to phy

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